Who We Are


  • 2000

    Nexus Medical, LLC began in 2000 when the U.S. Army Medical Material Command in Fort Detrick Maryland awarded a grant to research unintentional blood reflux into IV catheters and prevent the many unintended consequences it caused the Warfighters.

  • 2001

    Nexus Medical’s engineers learned blood reflux was caused by a multiplicity of physiological (internal) and mechanical (external) pressure fluctuations in the patient’s closed IV system.

  • 2002

    Nexus Medical’s engineers studied the human factors associated with internal and external pressures causing blood reflux into peripheral IV catheters, midlines, PICC and CV catheters.

  • 2003

    Nexus Medical submitted the first FDA 510K for both a pre-slit septum needleless connector and a luer activated needleless connector with pressure activated anti-reflux diaphragm. We called the new anti-reflux needleless connector TKO (“To Keep Open”).

  • 2004

    The first clinical trials for the Nexus TKO-1 were conducted at Wilford Hall Medical Center, San Antonio, Texas, in the bone marrow transplant unit.

  • 2005

    While using the Nexus TKO®-5 on PICC and CVC lines, Wesley Medical Center reduced occlusion and tPA/alteplase consumption by 71% and eliminated Heparin maintenance flushing.

  • 2009

    FDA 510K cleared the first anti-reflux pressure-rated microbore and standard bore extension sets.

  • 2009

    Study published in the Journal of Infusion Nursing shows fewer occlusions and decreased costs when using the TKO needleless connector compared to a neutral connector.

  • 2012

    Nexus Medical received FDA 510K clearance on the first luer-activated TKO anti-reflux technology and launched the TKO®-6.

  • 2012

    Nexus Medical receives FDA 510K clearance and launches a complete line of neonatal and pediatrics infusion extension sets, blood gas sampling sets, bi-, tri-, and quad-furcated extension sets and manifold sets.

  • 2014

    Nexus TKO®-6P received FDA 510K clearance and Nexus Medical launched the pressure-rated version of the luer-activated TKO anti-reflux technology.

  • 2016

    Nexus introduces the TKO 6P-HV (High Visibility) needleless connector and extension sets for home infusion therapy patients.

  • 2018

    Study demonstrates that TKO has the least amount of reflux compared to 14 commercially available needleless connectors (published in the Journal of Vascular Access)

  • 2018

    Research demonstrates a 69% reduction in occlusions using TKO compared to a neutral connector (published in the Journal of Association of Vascular Access).

  • 2020

    Study published in the Journal of the Association of Vascular Access demonstrates that TKO has the least of amount of reflux and bi-directional flow control compared to 13 commercially available needleless connectors.

  • 2021

    2021 Infusion Therapy Standards of Practice (8th edition) notes that anti-reflux needleless connectors designed with a bidirectional, pressure-sensitive diaphragm require no specific clamping sequence and offer the least amount of blood reflux.

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Latest News

Read the latest news and research about Nexus Medical products.


Explore how occlusions form, helpful hints, researcher presentations and more information on the Nexus TKO.

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Case Studies

Learn how Nexus TKO helps improve patient care, cut costs and streamline the IV therapy process.

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