Nexus TKO®
Evidence

“As documented in over 25 published studies, our patients have benefitted from significant reductions in vascular catheter occlusions using the Nexus TKO to replace the previous neutral connector.”

-IV TEAM LEAD, NORTHEAST
LEVEL 1 TRAUMA CENTER

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Nexus TKO® improves patient safety and clinical outcomes
while reducing costs and complications.

Nexus TKO® needleless connectors reduce the chances of catheter occlusions. See the published studies and evidence below.

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Successful CLABSI Reduction Strategies

Poster presented at the 2015 AVA Scientific Meeting
Ayers H.
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The Role of the Hemodilution Ratio…

Presented at the 2019 AVA Annual Scientific Meeting
Foor, J., Moureau, N.
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Do Needleless Connector Manufacturer Claims…

iPoster: Presented at the 2020 AVA Scientific Meeting
Gibson, M.
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Reduction in Central Line Occlusions and the Elimination of Heparin in Home Infusion Patients

Presented at the 2014 Infusion Nurses Society Conference
Harris, L.
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Reduction in Catheter Occlusion in Home Infusion by Implementing an Anti-reflux Needleless Connector

Presented at the 2015 National Home Infusion Association Conference
Harwood, P.
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Quantitative Assessment of Reflux in Commercially Available Needless IV Connectors

Presented at the 2015 National Home Infusion Association Conference
Hull, G.
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Quantitative Assessment of Catheter Reflux in Commercially Available Needleless Connectors

iPoster: Presented at the 2015 Infusion Nurses Society Conference
Hull, G., Sengupta, S.
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Occlusion Reduction and Heparin Elimination Trial Using an Anti-Reflux Device on Peripheral and Central Venous Catheters

Presented at the 2008 Infusion Nurses Society Conference
Jasinsky, L., Wurster, J.
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Anti-reflux Technology Reduces Catheter Consumption and Provides Significant Cost Savings

Presented at the 2014 Infusion Nurses Society Conference
Shomo, J., Reynolds, C.
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The Five-Year Impact of a VAST Using Lean IV Care to Reduce CVAD Occlusions

iPoster: Presented at the 2020 Association for Vascular Access Scientific…
Steere, L.
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Transforming Intravenous Practices: Cost Savings, Better Patient Outcomes

Presented at the 2020 Association for Vascular Access Scientific Meeting
Steere, L., Ficara, C.
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The Power of a VAST in Improving Patient Satisfaction & Reimbursements

iPoster: Presented at the 2020 Association for Vascular Access Scientific…
Steere, L.
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Reaching One Peripheral IV Per Patient Visit with Lean Multi-Modal Strategy: The PIV5Rights Bundle

iPoster: Presented at the 2019 Association for Vascular Access Scientific…
Steere, L., Ficara, C.
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Reduction in Central Venous Catheter Infections and Occlusions

Examining the Clinical Impact of a Pressure Activated Anti-Reflux Connector.…
Steere, L.
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A Quinfecta: Five Rights for 1 PIVC Per Patient

Presented at the 2018 Institute for Healthcare Improvement Meeting
Steere, L.
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Reduce PIVC Complications and Costs Using the Five Rights Approach A Randomized,

Controlled Trial – Presented at the 2018 Association for Vascular…
Steere, L., Sullivan, D.
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Maximizing the Midline

Presented at the 2015 Association for Vascular Access Scientific Meeting
Valentino, R., Farkas, V.
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Theoretic Methodology and Systematic Evidence Review of the PIV5Rights Insertion Care Bundle

iPoster: Presented at the 2020 Association for Vascular Access Scientific…
Moureau, N., Steere, L.
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How to be Flow Righteous

Presented at the 2010 Association for Vascular Access Scientific Meeting…
Moureau, N.
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Achieving Peak Catheter Performance Through Reflux Valve Protection: Reducing Catheter Occlusions and Failure

iPoster: Presented at the 2020 Association for Vascular Access Scientific…
Moureau, N., Jasinsky, L.
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Image of Buzas Keeping You Connected Research Poster

Keeping You Connected: Anti-Reflux Connectors Reduce Catheter Occlusions and Use of Alteplase

Presented at the National Home Infusion Association 2021 Annual Conference
Buzas, B.
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Quantitative Assessment of Catheter Reflux in Commercially Available Needleless Connectors

Hull, G., Sengupta, S.
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The Five-Year Impact of a VAST Using Lean IV Care to Reduce CVAD Occlusions

Presented at the 2020 Association for Vascular Access Scientific Meeting
Steere, L.
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The Power of a VAST in Improving Patient Satisfaction & Reimbursements

Presented at the 2020 Association for Vascular Access Scientific Meeting
Steere, L.
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Reaching One Peripheral IV Per Patient Visit with Lean Multi-Modal Strategy: The PIV5Rights Bundle

Presented at the 2019 Association for Vascular Access Scientific Meeting
Steere, L., Ficara, C.
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Theoretic Methodology and Systematic Evidence Review of the PIV5Rights Insertion Care Bundle

Presented at the 2020 Association for Vascular Access Scientific Meeting
Moureau, N., Steere, L.
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Achieving Peak Catheter Performance Through Reflux Valve Protection: Reducing Catheter Occlusions and Failure

Presented at the 2020 Association for Vascular Access Scientific Meeting
Moureau, N., Jasinsky, L.
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How to Become Flow Righteous: The 1-2-3 Elements of Success

Presented at the 2020 Association for Vascular Access Scientific Meeting
Moureau, N.
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Do Needleless Connector Manufacturer Claims on Bidirectional Flow and Reflux Equate to In Vitro Quantification of Fluid Movement?

Journal of the Association for Vascular Access (2020) 25 (4):…
Gibson, M.
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Quantitative Assessment of Catheter Reflux in Commercially Available Needless IV Connectors

Journal of Vascular Access. December 2017
Moureau, N., Hull, G., Sengupta, S.
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Occlusion Reduction and Heparin Elimination Trial Using an Anti-Reflux Device on Peripheral and Central Venous Catheters

Journal of Infusion Nursing. 2009. 32(1):33-39
Jasinsky, L., Wurster, J.
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Lean Six Sigma for Intravenous Therapy Optimization: A Hospital Use of Lean Thinking to Improve Occlusion Management

JAVA. March 2018. Vol 23 No 1. Pg. 42-50
Steere, L.
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Reaching One Peripheral IV Per Patient Visit with Lean Multi-Modal Strategy: The PIV5Rights Bundle

JAVA. 2019;24(3):31-43
Steere, L., Ficara, C.
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Reducing Catheter Occlusions and Failures

Healthcare Hygiene Magazine, February 2021
Moureau, N.
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Preventing Intraluminal Occlusion in Peripherally Inserted Central Catheters

British Journal of Nursing 2016. Vol. 25. No.19. Pg. s12-s18
Hitchcock, J.
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The Right Approach for the Right Result: Applying Lean Leadership to Achieve Standard Work in IV Therapy

PSQH [Internet]. 2020 Oct 8 [cited 2020 Oct 8]
Steere, L., Ficara, C.
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The Right Approach for the Right Result: Applying Lean Leadership to Achieve Standard Work in IV Therapy

Nurse Leader [Internet]. 2020 Oct 9 [cited 2020 Oct 9]
Steere, L., Ficara, C.
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Reducing the occlusion rates of peripheral Midlines: Our 5-year experience using Bionector TKO needle free connectors

Presented at the 2016 National Health System CDDFT Meeting (UK)
Maurer, A.
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PIC and Midline Catheter Occlusion Rates

White Paper 2007: A prospective study comparing the Interlink Split…
Mitch, S., Brandmeyer, B.
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Revolutionary Change in IV Therapy Utilizing LifeShield® TKO-5® Anti-Reflux Device

White Paper. 2008
Mitch, S.
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Reducing the Risk of Catheter-Related Complications: Evaluation of the LifeShield™ TKO-5®Anti-Reflux Device in Two Hospitals.

Shomo, J., Paquet, F.
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96-Activation Microbial Barrier Performance Study

Nexus Medical GLP-Lab Study. Nexus TKO®-6P
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Mechanical Hemolysis Study

Nexus Medical GLP-Lab Study. Nexus TKO®-6P
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Blood Clearance Study

Nexus Medical GLP-Lab Study. Nexus TKO®-6P
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Septum Insertion Force Study of Nexus TKO®-6P

Septum and other Market Leading Needleless Connectors
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Nexus Medical ISO 594 – Primary Standard for Luer Fittings

Luer and Locking Thread Comparisons: Dimensional Study of Nexus TKO®-6P…
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Nexus TKO®-6P: Biocompatibility & Chemical Compatibility Technical Specification

FDA Premarket Notice – Nexus Medical 510(k): K130416
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Nexus TKO-6P: FDA 510K Premarket Notification

FDA Premarket Notice – Nexus Medical 510(k): K130416
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Certificate of Registration

Quality Management System – ISO 13485:2016
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FDA 510K for Nexus TKO-6P Anti-Reflux Needleless Connector

Regulation Number: 21 CFR 880.5440
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FDA 510K for Nexus Pressure Rated Extension Sets

Regulation Number: 21 CFR 880.5440
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Certificate of Registration

Quality Management System – ISO 13485:2016
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FDA 510K for Nexus TKO-6P Anti-Reflux Needleless Connector

Regulation Number: 21 CFR 880.5440
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Nexus TKO®-6P Directions for Use

English and French versions N-DL-GENDFU-Rev B
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Preventing the Cascade of Complications from Reflux

Presented at the 2021 Association for Vascular Access Scientific Meeting
Hughey, J.
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Preventing Complications: The Success of Anti-Reflux Needleless Connectors

Presented at the 2022 NHIA Annual Conference
Buzas, B.
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CLEAR Study: 5-Year Impact of LEAN Occlusion Management

Clinical Nurse Specialist journal March/April 2022
Steere, L.
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Get 24/7 IV Protection

Reduce the occurrences of occlusions and infiltrates and the high cost of tPA, Heparin and IV catheter replacements.

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