“Anti-reflux needleless connectors containing a bidirectional, pressure-sensitive diaphragm have the least amount of reflux”
Why Nexus TKO® Needleless Connectors
Nexus TKO® (To Keep Open) is engineered to produce the least amount of blood reflux and occlusions in IV catheters, which meets the 2021 INS Standards of Practice.
TKO Pressure Activated Anti-Reflux diaphragm automatically opens and closes based upon physiological and mechanical pressure changes which prevents unintentional blood reflux without any change in clinical practice.

Nexus TKO® Difference
Nexus TKO needleless connector provides bi-directional flow control and meets the definition for anti-reflux needleless connectors in the 2021 Infusion Therapy Standards of Practice.
The TKO infusion device has a proprietary 3-position silicone diaphragm which opens and closes based upon mechanical and physiologic pressure changes in a closed IV system.

Nexus TKO® Performance
Evidence indicates that traditional needleless connectors, such as negative displacement, positive displacement and neutral, do not have the least amount of reflux, according to the 2021 INS Standards [36.B.3].
Anti-Reflux technology has the least amount of reflux due to the internal mechanism which is a 3-position pressure-activated silicone diaphragm.
Select your needleless connector below.
How does it compare to TKO?
Needleless Connector Results: Ranked by Reflux Amount
- Reflux, Amount of Fluid/Blood pulled into a Catheter Lumen
- Infusion, Amount of Fluid/Infusate pushed into a Vein















22 gauge PIV; 1” of Catheter = 8.42µL (+/-0.5µL) 1µL = 1mm3
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100 - |
75 - |
50 - |
25 - |
0
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0 - |
25 - |
50 - |
75 - |
100
22 gauge PIV; 1” of Catheter = 8.42µL (+/-0.5µL) 1µL = 1mm3

Designed to Protect
TKO 3-Position Diaphragm prevents unintentional blood reflux from mechanical and physiological pressure changes in closed IV system

Microbial Protection
TKO Tri-Seal™ Design is validated and provides 3-Levels of Microbial Barrier Protection for your patient’s

Proven Performance
TKO performance is documented in over 25-studies demonstrating efficacy and improvements in patient outcomes, safety and satisfaction
Nexus Medical Products
Nexus Medical offers a wide array of IV products for acute care, home infusion, long-term care, neonatal, pediatric, pharmacy, EMS patients and more.
We offer a wide range of IV product sets, including filter, blood collection, administration, gravity and secondary sets, as well as flow regulators, and single, bifurcate, trifurcate or quadfurcate extension set configurations. Our soft, flexible tubing is designed for ease of use and power injectable to 325psi or 10 mL per second. Tubing sizes include microbore, standard bore, minibore and ultra-microbore.



NEXUS TKO-6P HV WITH GREEN GRIP FOR HOME INFUSION
NEXUS TKO NEONATAL EXTENSION SETS
NEXUS TKO POWER INJECTION EXTENSION SETS
Nexus TKO® Product Resources
Nexus offers a wide range of virtual and face-to-face educational resources for healthcare providers and patients. Gain access to presentations for continuing education, podcasts, posters, and other materials.
Get 24/7 IV Protection
Reduce the occurrences of occlusions and infiltrates and the high cost of tPA, Heparin and IV catheter replacements.