“Anti-Reflux needleless connectors designed with a bi-directional, pressure-sensitive diaphragm require no specific clamping sequence to prevent reflux.”
Nexus TKO®
Performance
2021 Infusion Therapy Standards of Practice (8th edition)
Does your Needleless Connector Meet the 2021 Infusion Therapy Standards of Practice?
Review a summary of the INS needleless connector standards (36).
Proven Performance That Meets the 2021 Infusion Therapy Standards of Practice
Nexus TKO is the best and proven needleless connector to produce the least amount of thrombotic occlusions and blood reflux compared to other types of needle-free connectors.
Select your needleless connector below.
How does it compare to TKO?
Needleless Connector Results: Ranked by Reflux Amount
- Reflux, Amount of Fluid/Blood pulled into a Catheter Lumen
- Infusion, Amount of Fluid/Infusate pushed into a Vein















22 gauge PIV; 1” of Catheter = 8.42µL (+/-0.5µL) 1µL = 1mm3
- |
100 - |
75 - |
50 - |
25 - |
0
- |
0 - |
25 - |
50 - |
75 - |
100
22 gauge PIV; 1” of Catheter = 8.42µL (+/-0.5µL) 1µL = 1mm3
Blood Reflux Performance Comparison
Nexus TKO® is NOT Negative or Positive displacement, it’s Anti-Reflux.
Older traditional needleless technologies provide needle stick injury protection but were not designed:
- To protect the patient from unintentional blood reflux from physiological and mechanical pressure changes in a closed IV system
- To protect the patient’s IV catheter from thrombotic catheter occlusions when proper clamping
sequence is not performed

Evidence-Based Performance Results
Nexus TKO® anti-reflux technology is proven in multiple scientific and clinical studies to provide blood reflux protection 24/7, which improves patient safety, satisfaction and provides better hospital economics.
Improving Patient Safety
• Reduce IV complications such as thrombotic catheter occlusions, infiltrations and phlebitis
• Reduces Infections, UF Health, successful CLABSI reduction strategy
• Improves Blood Sampling, New York Methodist Hospital midline and PICC blood sampling
• Maintains a closed IV system without exposing clinician to blood splashing and leaks
Improve Patient Satisfaction Scores
• Longer Dwell Time = Fewer IV Restarts, Hartford Health System PIV5Rights®
• 89% First Stick Success, Steere reaching one peripheral IV study
Better Hospital Economics
• Reduce Pharmacy costs, tPA, Heparin maintenance flushing
• tPA/Alteplase and Heparin, JIN published article
• Reduced IV Supply Costs, 38% supply cost reduction

Nexus TKO® Competitive Comparison
Nexus TKO® Product Resources
Nexus offers a wide range of virtual and face-to-face educational resources for healthcare providers and patients. Gain access to presentations for continuing education, podcasts, posters, and other materials.
Get 24/7 IV Protection
Reduce the occurrences of occlusions and infiltrates and the high cost of tPA, Heparin and IV catheter replacements.